Endocrine dysfunction in transfusion dependent thalassemia patients from central India

Background: Thalassemia refers to a group of genetically inherited diseases characterized by decreased or absent synthesis normal globin chains resulting in defective chains. Most the available studies literature have been done adults and there is paucity highlighting prevalence hormonal dysfunction transfusion dependent patients pediatric age group. We conducted present study with an aim estimate thalassemia (TDT) at tertiary care center Central India. Aims Objectives: The was TDT central Materials Methods: It descriptive cross-sectional hospital MGM Medical College, Indore, Madhya Pradesh, over period 12 months (August 2021–July 2022). Results: Our recruited total 100 children ranging from 9 year 18 years mean 13.16±2.86 years. Sixty percent (n=60) our population were males 40% (n=40) females. hypogonadism 35.18% analyzed 54 patients, hypothyroidism 10%, diabetes 5%. Although serum ferritin very elevated all endocrine dysfunction; statistically significant association found between (P=0.020). Conclusion: Patients are often associated endocrinopathies; most commonly hypogonadism, followed diabetes. Early screening treatment necessary improve their outcome.